MISO¶

Description¶

MISO (Mixture-of-Isoforms) is a probabilistic framework that quantitates the expression level of alternatively spliced genes from RNA-Seq data, and identifies differentially regulated isoforms or exons across samples. By modeling the generative process by which reads are produced from isoforms in RNA-Seq, the MISO model uses Bayesian inference to compute the probability that a read originated from a particular isoform. The MISO framework is described in Katz et. al., Analysis and design of RNA sequencing experiments for identifying isoform regulation. Nature Methods (2010).

Environment Modules¶

Run module spider miso to find out what environment modules are available for this application.

Environment Variables¶

HPC_MISO_DIR - installation directory
HPC_MISO_BIN - executable directory

Categories¶

biology, ngs, sequencing, rna-seq