METAL¶
Description¶
METAL is a tool for meta-analysis genomewide association scans. METAL can combine either (a) test statistics and standard errors or (b) p-values across studies (taking sample size and direction of effect into account). METAL analysis is a convenient alternative to a direct analysis of merged data from multiple studies. It is especially appropriate when data from the individual studies cannot be analyzed together because of differences in ethnicity, phenotype distribution, gender or constraints in sharing of individual level data imposed. Meta-analysis results in little or no loss of efficiency compared to analysis of a combined dataset including data from all individual studies.
Environment Modules¶
Run module spider metal to find out what environment modules are available for this application.
Environment Variables¶
- HPC_METAL_DIR - installation directory
- HPC_METAL_BIN - executable directory
- HPC_METAL_DOC - documentation directory
- HPC_METAL_EX - examples directory
Citation¶
If you publish research that uses metal you have to cite it as follows:
Cristen J. Willer, Yun Li, Gonçalo R. Abecasis, METAL: fast and efficient meta-analysis of genomewide association scans, Bioinformatics, Volume 26, Issue 17, September 2010, Pages 2190–2191, https://doi.org/10.1093/bioinformatics/btq340
Categories¶
biology, ngs, genomics