MACS¶

Description¶

MACS stands for Model-based Analysis of ChIP-Seq on short read sequencers such as Genome Analyzer (Illumina / Solexa). MACS empirically models the length of the sequenced ChIP fragments, which tends to be shorter than sonication or library construction size estimates, and uses it to improve the spatial resolution of predicted binding sites. MACS also uses a dynamic Poisson distribution to effectively capture local biases in the genome sequence, allowing for more sensitive and robust prediction.

Environment Modules¶

Run module spider macs to find out what environment modules are available for this application.

Environment Variables¶

HPC_MACS_DIR - installation directory
HPC_MACS_BIN - executable directory

Citation¶

If you publish research that uses macs you have to cite it as follows:

Zhang et al. Model-based Analysis of ChIP-Seq (MACS). Genome Biol (2008) vol. 9 (9) pp. R137

Categories¶

biology, chip-seq