MACH

Description

mach website

Genome-wide association studies (GWAS) can identify common alleles that contribute to complex disease susceptibility. The effects of most common SNPs must be evaluated indirectly using either genotyped markers or haplotypes thereof as proxies. MACH software implements a computationally efficient Markov Chain framework for genotype imputation and haplotyping. The approach describes sampled chromosomes as mosaics of each other and uses available genotype and shotgun sequence data to estimate unobserved genotypes and haplotypes, together with useful measures of the quality of these estimates.

Environment Modules

Run module spider mach to find out what environment modules are available for this application.

Environment Variables

• HPC_MACH_DIR - installation directory
• HPC_MACH_BIN - executable directory

Citation

If you publish research that uses mach you have to cite it as follows:

Li Y, Willer CJ, Ding J, Scheet P and Abecasis GR (2010) MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes. Genet Epidemiol 34:816-834.

Li Y, Willer CJ, Sanna S and Abecasis GR (2009) Genotype Imputation. Annu Rev Genomics Hum Genet 10:387-406.

Categories

biology, genomics, ngs