EvoLSTM¶

Description¶

A recurrent neural network-based evolution simulator that captures mutational context dependencies. EvoLSTM uses a sequence-to-sequence long short-term memory model trained to predict mutation probabilities at each position of a given sequence, taking into consideration the 14 flanking nucleotides. EvoLSTM can realistically simulate mammalian and plant DNA sequence evolution and reveals unexpectedly strong long-range context dependencies in mutation probabilities. EvoLSTM brings modern machine-learning approaches to bear on sequence evolution. It will serve as a useful tool to study and simulate complex mutational processes.

Environment Modules¶

Run module spider evolstm to find out what environment modules are available for this application.

Environment Variables¶

HPC_EVOLSTM_DIR - installation directory
HPC_EVOLSTM_BIN - executable directory

Categories¶

biology